The P-I-E-N-O Parkinsn's List Drug Database

biperiden /Akineton^TM

ANTIPARKINSON:

Anticholinergic

Description: Biperiden is an oral and parenteral antimuscarinic agent used as adjunct treatment for Parkinson's disease and for the relief of extrapyramidal symptoms associated with antipsychotic agents. The antimuscarinic activity relieves muscle rigidity, reduces sweating and salivation, improves gait, and decreases tremor activity. This drug was approved by the FDA in 1959.

Contraindications: Angle-closure glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcer disease, prostatic hypertrophy, bladder neck obstruction, myasthenia gravis, megacolon.

Drug Interactions: Anticholinergic agents, other: Can increase the risk of developing adverse anticholinergic effects.

Adverse Reactions: Xerostomia, blurred vision, parotitis, nausea/vomiting, drowsiness, dizziness, mental confusion. Parenteral administration: transient hypotension, coordination disturbances, temporary euphoria.

Dosage: For treatment of parkinsonism: 2 mg PO tid or qid, adjusting dosage according to response and tolerance. Maximum dose is 16 mg/day.

For treatment of drug-induced extrapyramidal symptoms:

Oral: 2 mg PO 1-3 times daily.

IV/IM: 2 mg biperiden lactate solution IM or slow IV every 30 minutes according to response and tolerance, to a maximum of four doses (8 mg) per day.

Children: 40 æg/kg or 1.2 mg/m BSA every 30 minutes according to response and tolerance, to a maximum of four doses per day.

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