The P-I-E-N-O Parkinsn's List Drug Database

domeperidone / Motilium^TM

PROMOTILITY:

Description: Domperidone is an investigational antiemetic to be used with cancer chemotherapy. It has also shown efficacy in the treatment of gastroesophageal reflux disease (GERD).

Actions: antagonist at dopaminergic receptors, similar to phenothiazines and metoclopramide.

Uses: under investigation for treatment of chemotherapy-induced nausea/vomiting; potentially useful in gastroesophageal reflux disease (GERD).

Distinguishing Features: Domperidone crosses the blood-brain barrier more poorly than phenothiazines or metoclopramide, thus, extrapyramidal reactions are uncommon. Unlike metoclopramide, effects of domperidone on gastric motility are not antagonized by atropine. Bioavailability is 15%; T« ranges 7-8 hours.

Major Adverse Reactions: hyperprolactinemia;

Usual Adult Dosage: doses of 40-120 mg PO have been used in the treatment of gastric hypomotility.

Manufacturer: Janssen Pharmaceuticals. (800)-526-7736.

Status: Currently used in Europe; NDA originally submitted in 1985 and resubmitted in 1991; as of 4/6/95, not yet approved for use in the US (verbal communication)

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