The P-I-E-N-O Parkinsn's List Drug Database

ethopropazine / Pardidol^TM ANTIPARKINSON: Antimuscarinic

Description: Ethopropazine is an oral antimuscarinic agent used as adjunct treatment for Parkinson's disease and for the relief of drug-induced extrapyramidal reactions. The antimuscarinic activity relieves muscle rigidity, reduces sweating and salivation, improves gait, and decreases tremor activity. This drug was approved by the FDA in 1953.

Contraindications: Angle-closure glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcer disease, prostatic hypertrophy, bladder neck obstruction, myasthenia gravis, megacolon.

Drug Interactions: Anticholinergic agents, other: Can increase the risk of developing adverse anticholinergic effects. Adverse Reactions: Xerostomia, blurred vision, parotiditis, nausea/vomiting, drowsiness, dizziness, mental confusion.

Dosage: Initially, 50 mg PO once or twice daily, increasing if necessary and as tolerated to a maximum of 600 mg per day.

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