The P-I-E-N-O Parkinsn's List Drug Database

ropinerole / Requip^TM

ANTIPARKINSON:

Dopamine Agonist:

Ropinirole is a potent, highly selective, dopamine agonist, not related to pramipexole or the ergot derived drugs, developed for early therapy in Parkinson's disease patients not yet treated with levodopa and as adjunct therapy in treating Parkinson's disease patients not optimally controlled on levodopa. This potent D2- dopamine agonist is active both centrally and peripherally with central nervous system and cardiovascular activity seen. Antidepressant and anxiolytic effects have also been noted in patients with Parkinson's disease. Evidence of a possible neuroprotective effect has been documented. More than 300 patients with Parkinson's disease have completed placebo-controlled studies of ropinirole, taking doses up to 10 mg daily. Typical dopamineric side effects such as nausea, vomiting and orthostatic hypotension may occur at doses above 0.5 mg. Incremental dosage increases minimize these side effects, and the drug is tolerated extremely well by the majority of patients. A three times daily dosing schedule of lower doses given with meals allows for fewer side effects and closer conformance to it's half-life of 3.5-5 hours.

Requip^TM has been approved by the FDA

See the insert pages for specifics.

To Page 1 of ropinerole/Requip^TM Insert

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