The P-I-E-N-O Parkinsn's List Drug Database

trimethobenzamide / Tigan^TM , Trimazide^TM , Arrestin^TM

ANTIVOMITING: Antiemitic: MODERATE RISK

Description: Trimethobenzamide is an oral, rectal, and parenteral antiemetic agent. It is used to control nausea and vomiting. Trimethobenzamide's mechanism of action is unknown, but it may be mediated through the chemoreceptor zone. Use with caution in children, especially when vomiting could be symptomatic of Reye's syndrome. There is a possibility that centrally acting antiemetics in combination with viral illness could lead to the development of Reye's syndrome. This drug was approved by the FDA in 1959.

Contraindications: Hypersensitivity to benzocaine or similar anesthetics, pregnancy.

Drug Interactions: No significant interactions. ADVERSE REACTIONS: Parkinson-like symptoms, hypotension, blood dyscrasias, blurred vision, coma, convulsions, depression, diarrhea.

Dosage: Oral dosage: Adults: 250 mg PO tid or qid as needed. Children: 100-200 mg PO tid or qid as needed.

Intramuscular dosage: Adults: 200 mg IM tid or qid as needed.

Rectal dosage: Adults: 200 mg PR tid or qid as needed. Children 15-45 kg: 100-200 mg PR tid or qid as needed. Children < 15 kg: 100 mg PR tid or qid as needed.

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