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Pergolide

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MedWatch - The FDA Safety Information and Adverse Event Reporting  Program

FDA notified healthcare professionals and patients that companies  that
manufacture and distribute pergolide have agreed to withdraw the  drug
from the market.  Pergolide is a dopamine agonist (DA) used  with
levodopa and carbidopa to manage the signs and symptoms of  Parkinson's
disease. Results of two new studies showed that some patients  with
Parkinson's disease treated with pergolide had serious damage to  their
heart valves when compared to patients who did not receive the  drug.
These two studies confirm earlier studies that also described  this
problem. Patients currently taking pergolide should contact  their
healthcare professional about alternate treatments and not abruptly  stop
taking their medication.  Healthcare professions should assess  their
patient's need for DA therapy.  If continued treatment with a DA  is
needed, another DA should be substituted for pergolide.




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