Re: 2000 yr old case of PD

[JOHN YOCHIM <jybiom@xxxxxxxxx>]

My Grandfather on my mothers side had PD. My whole family decends from German ancestry but we have no record of members having Pd except for the Grandfather. I wonder if there is a way to trace back to uncover past generations in the family? Not that it wll help me at this time. I am hoping that my children do not acquire the problem.
The spinal cord info looks promising. Thanks for all the updates.
John

--- On Fri, 3/20/09, rayilynlee <rayilynlee@xxxxxxx> wrote:
From: rayilynlee <rayilynlee@xxxxxxx>
Subject: Re: 2000 yr old case of PD
To: PARKINSN@xxxxxxxxxxxxxxxxxxxx
Date: Friday, March 20, 2009, 4:07 PM

Murray and Steve

I blame my grandfather for my PD.  He was a disagreeable guy so it helps to
have someone to blame, I think.

However, nobody deserves this disease.

Ray

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
rbrown@xxxxxxxxx

--------------------------------------------------
From: "Steve Rack" <srack@xxxxxxxxx>
Sent: Tuesday, March 17, 2009 2:18 PM
To: <PARKINSN@xxxxxxxxxxxxxxxxxxxx>
Subject: Re: 2000 yr old case of PD

>> PARKINSON'S DISEASE NEWS
>> from Viartis
>> 
>> 16th March 2009 - New research
>> 2000 YEAR OLD CASE OF PARKINSON'S DISEASE
>> 
>> Neurogenetics [2009] Mar 13. [Epub ahead of print] (Bar-Shira A,
Hutter CM, Giladi N, Zabetian CP, Orr-Urtreger A.) Complete abstract
>> 
>> It is often claimed that Parkinson's Disease was discovered in
1817 by James Parkinson. However, there have been descriptions and treatments of
Parkinson's Disease since ancient times. For more information go to the
History of Parkinson's Disease. There is a genetic mutation called LRRK2
G2019S that increases the likelihood of Parkinson's Disease. It is most
common amongst Ashkenazi Jews. Ashkenazi Jews descend from Jews in medieval
Germany. It was found that Ashkenazi Jews who had Parkinson's Disease due to
this genetic mutation had a common ancestor who lived nearly 2000 years ago.
Their ancestor, who would have probably had Parkinson's Disease, lived
approximately 1,830 (1,560-2,160) years ago, around the second century A.D.,
after the second Jewish Diaspora.
> 
> Thanks Ray.
>  Now I have someone to point a finger at. My mom's father emigrated
from Hamburg. He died young so we will never know if he had Pd. Now, for what
it's worth, we can blame Grandpa for Mom's and my Pd.
> I just reread this and it seems I've let some bitterness out. Maybe
I'd rather I didn't know about this. Another learning experience I
suppose.
> -- Steve in VT
> 
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