partial agonist

[mschild <mmoo@xxxxxxxxxxx>]

9th March 2010 - New research
PARDOPRUNOX - A PARTIAL DOPAMINE AGONIST FOR PARKINSON'S DISEASE 
Movement Disorders [2010] Mar 2. [Epub ahead of print] (Bronzova J, Sampaio C, 
Hauser RA, Lang AE, Rascol O, Theeuwes A, van de Witte SV, van Scharrenburg G) 
  Complete abstract
                                                                                
                                                                                
                 
Pardoprunox is a new partial dopamine agonist from Solvay being assessed for 
its potential future use in the treatment of Parkinson's Disease. It unusually 
combines two effects as if it were two distinct but combined drugs :  
partially stimulating dopamine, whose deficiency causes Parkinson's Disease, 
and fully stimulating serotonin, which is another chemical naturally produced 
in the brain. It is thought that Pardoprunox could avoid some of the severe 
side effects that full dopamine agonists cause by lessening the effect of 
dopamine when dopamine activity is high. This study examined the efficacy and 
safety of Pardoprunox (SLV308), in the treatment of patients with early 
Parkinson's Disease. Parkinson's Disease symptoms did reduce when taking 
Pardoprunox. Activities of daily living in people with Parkinson's Disease 
also improved. Nausea was reported by 47% of patients. Dizziness, somnolence, 
headache, asthenia were reported far less commonly. The effects of Pardoprunox 
are to be assessed further. 

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